解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Activation of enzyme phospholipase A2 (EC 3.1.1.4), the major liberator of arachidonic acid, has been proposed as a component in the pathogenesis of inflammatory bowel disease. To test the hypothesis that phospholipase A2 activity is increased in ulcerative colitis, enzyme activity was investigated in colonic biopsies...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200753
更新日期:1991-01-01 00:00:00
abstract::Neutrophil motility in normal subjects and Crohn's disease patients was assessed using both double and single filter assay systems with n-formylmethionylleucylphenylalanine (FMLP) as the attractant, and in a single filter assay with Candida albicans in 10% serum as the attractant. Assays were performed in triplicate a...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200680
更新日期:1991-01-01 00:00:00
abstract::Rats were given 59Fe (28 micrograms) together with doses of 0, 2 and 200 micrograms of uroporphyrin III in paired observations. Absorption of 59Fe was determined by comparing whole body counts of the rats 30 min and 7 days after dosing. Prior treatment with 200 micrograms of uroporphyrin twice daily for 3 days was ass...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200714
更新日期:1991-01-01 00:00:00
abstract::Several previous studies have shown that the plasma concentration of gamma-amino-butyric acid (GABA) is markedly increased in patients with hepatic encephalopathy, and it has been suggested that decreased metabolism of peripheral GABA might contribute to the cerebral dysfunctions observed. In the present study, plasma...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200724
更新日期:1991-01-01 00:00:00
abstract::By immunohistochemistry and double staining technique, almost complete coexistence of galanin-like immunoreactivity (GAL-LI) and vasoactive intestinal polypeptide-like immunoreactivity (VIP-LI) was demonstrated in submucosal ganglionic cells and mucosal nerve fibers of the porcine ileum. The release of the two neurope...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200741
更新日期:1991-01-01 00:00:00
abstract::Chemiluminescence (CL) is a simple quantitative assay of polymorphonuclear leucocyte (PMNL) oxidative metabolism. PMNL CL was found to be significantly higher in patients with chronic inflammatory bowel disease than in normal controls (167 +/- 60 vs. 139 +/- 50 mV/10(5) cells, p less than 0.05). There were no signific...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200238
更新日期:1990-01-01 00:00:00
abstract::N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine HCl (DPPE) is an antihistamine with a unique profile of activity in the stomach. It is antisecretory and blocks the formation of experimental cold/stress- and ethanol-induced gastric lesions, as well as cysteamine-induced duodenal ulcers in a fashion more potent than o...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200489
更新日期:1990-01-01 00:00:00
abstract::Rabbit duodenal and jejunal brush-border membrane vesicle integrity, fluidity and passive proton permeability were studied after in vitro exposure to deoxycholate, glycodeoxycholate or taurodeoxycholate. Duodenal and jejunal membrane mean vesicle volume [0.54 (0.05) and 0.54 (0.03) microliters/mg, mean values with SE ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200498
更新日期:1990-01-01 00:00:00
abstract::Cholecystokinin (CCK) is known to inhibit gastric acid secretion and gastric emptying but its physiological role in the inhibition of gastric functions is not settled. In this study performed on 16 young male subjects, gastric acid secretion and emptying rate were determined after intragastric administration of 8% pep...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200218
更新日期:1990-01-01 00:00:00
abstract::Life-long administration (greater than or equal to 2 years) of a number of long-acting gastric acid inhibitors (including H2-receptor antagonists, omeprazole and ciprofibrate) has been associated with the development of gastric enterochromaffin-like cell (ECL cell) carcinoids in rats. It has been postulated that they ...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000200510
更新日期:1990-01-01 00:00:00
abstract::The prognosis for the acute healing of patients with persistent, erosive or ulcerative reflux oesophagitis depends upon the choice of drug treatment as well as the severity of the initial oesophagitis. The results of this study show that omeprazole, 40 mg once daily (n = 51), is more effective than ranitidine, 300 mg ...
journal_title:Digestion
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000200522
更新日期:1990-01-01 00:00:00
abstract::Mucosal intestinal cells migrate and differentiate simultaneously as they move out of the crypts to their functional site along the villus. Interactions between the enterocyte basal membrane domain and the extracellular intestinal basement membrane (IBM) have been suggested to be essential to both cell migration and d...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200363
更新日期:1990-01-01 00:00:00
abstract::This study was undertaken to evaluate the effect of metoclopramide on transmural oesophageal variceal pressure and portal blood flow in cirrhotic patients. Sixteen cirrhotics were randomly assigned to metoclopramide (10 mg i.v.) or saline. Metoclopramide significantly decreased transmural variceal pressure (15.7% decr...
journal_title:Digestion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000200477
更新日期:1990-01-01 00:00:00
abstract::Chornic exogenous administration of cholecystokinin octapeptide (CCK8) to rats led to a reduced sensitivity of pancreatic acinar cells to both CCK8 and carbachol stimulation without changes in affinity or number of CCK or muscarinic receptors. In addition, repeated feeding of camostate, a synthetic protease inhibitor ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200386
更新日期:1990-01-01 00:00:00
abstract::Nine patients with short bowel syndrome and high intestinal output received octreotide either intravenously (50-100 micrograms t.i.d.) or subcutaneously (100 micrograms b.i.d.) on 2 test days. In the 6 patients with net secretory output, there was a reduction in mean daily intestinal output of 0.5-5.0 kg; total daily ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200267
更新日期:1990-01-01 00:00:00
abstract::Recent studies have demonstrated the presence of both CCKA and CCKB receptors on dog and guinea pig pancreas. Although CCKA receptors are implicated in enzymatic secretion, biological effects of CCKB receptors are still unknown. We have previously found that a rat acinar pancreatic cell line (AR4-2J) possesses both re...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200381
更新日期:1990-01-01 00:00:00
abstract::Cell renewal in the duodenal mucosa of Mastomys was studied by autoradiography 1 and 24 h after intraperitoneal injection of tritiated thymidine. Non-specific duodenitis and duodenal ulceration were produced with a continuous infusion of histamine. Mucosal renewal in the duodenum of 30 control Mastomys was compared wi...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200226
更新日期:1990-01-01 00:00:00
abstract::Recent studies indicate that intestinal lamina propria T cells are highly specialized lymphocytes, which differ from T cells in other compartments of the immune system in several respects. In the present study phenotypic and functional characteristics of lamina propria T cells and their possible relation to mucosal gr...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000200398
更新日期:1990-01-01 00:00:00
abstract::Putrescine, the product of the ornithine decarboxylase (ODC)-catalyzed reaction, stimulates macromolecular synthesis in a duodenal crypt cell line, IEC-6 cells, grown in culture. In addition, supplementation of medium with putrescine alone reverses the inhibition of proliferation produced by inhibition of ODC with dif...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200412
更新日期:1990-01-01 00:00:00
abstract::The clinical relevance of cispride's stimulating effects on lower oesophageal motility was studied in 19 patients with documented (endoscopy, biopsy) grade II or III oesophagitis. Patients were treated for 8 or 16 weeks (depending essentially on whether the result was cure or failure) with 10 mg of cisapride four time...
journal_title:Digestion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000200231
更新日期:1990-01-01 00:00:00
abstract::The aim of this study was to examine the relative importance of the enzymes ornithine decarboxylase (ODC) and diamine oxidase (DAO) in intestinal polyamine metabolism in normal rats. To study this we measured jejunal and ileal DAO and ODC activities and polyamine levels 2 h after injecting, in non-fasting male Wistar ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200411
更新日期:1990-01-01 00:00:00
abstract::We have shown that dietary long-chain triglycerides and 16,16-dimethyl prostaglandin E2 enhance and aspirin impairs postresection mucosal adaptation in rats. The present studies examined the hypothesis that supplemental linoleic acid (LA) above the minimum requirement may enhance postresection mucosal adaptation throu...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199893
更新日期:1989-01-01 00:00:00
abstract::Omeprazole is a very potent and long-acting inhibitor of gastric acid secretion. These characteristics make the drug very suitable for the management of gastric acid hypersecretion and symptom relief in patients with the Zollinger-Ellison syndrome, and in the treatment of patients with ulcers resistant to histamine H2...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000200102
更新日期:1989-01-01 00:00:00
abstract::The effect of the new antiulcer agent plaunotol on the release of endogenous secretin and the pancreatic exocrine secretion was investigated in anesthetized rats. In 48 rats with pancreatic and biliary diversion, continuous intraduodenal infusion of plaunotol in 3 graded doses (5, 20 and 80 mg/h/rat) resulted in signi...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199903
更新日期:1989-01-01 00:00:00
abstract::Whether and to what extent the pancreas is involved in acute viral hepatitis is still unclear. In order to address this issue we evaluated serum and urinary amylase and isoamylase levels in 92 patients with acute viral hepatitis of different etiology and in 60 healthy volunteers. Furthermore, pancreatic structure and ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199831
更新日期:1989-01-01 00:00:00
abstract::Studies with short-term administration of omeprazole in patients with erosive or ulcerative reflux oesophagitis have demonstrated that strong inhibition of gastric acid secretion will become the therapy of choice for these patients. However, because reflux oesophagitis relapses rapidly when short-term treatment is dis...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000200103
更新日期:1989-01-01 00:00:00
abstract::Glycoprotein and protein production of isolated pig gastric mucosal cells were determined by the incorporation of N-acetyl-[14C]D-glucosamine ([14C]GlcNAc) and [3H]L-leucine ([3H]Leu) into acid-insoluble macromolecules (AIM). In four cell fractions (F1-F4), obtained by counterflow centrifugation, specific [14C]GlcNAc ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199889
更新日期:1989-01-01 00:00:00
abstract::There are many controversies concerning the treatment of hemorrhages of the upper gastrointestinal tract. In order to determine whether some currently used drugs, such as somatostatin (SST) and ranitidine, may be useful in the control of hemorrhages, we have conducted a controlled (not blind) study with alternate assi...
journal_title:Digestion
pub_type: 临床试验,杂志文章
doi:10.1159/000199876
更新日期:1989-01-01 00:00:00
abstract::Somatostatin (SST) has been shown to induce cholestasis in the dog and in the rat. In man, it is still unknown whether SST modifies bile formation. The present study was undertaken to examine the influence of SST on bile secretion in man. Two volunteers who had a total external biliary fistula received 1-hour SST infu...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199820
更新日期:1989-01-01 00:00:00
abstract::Diamine oxidase (DAO) is an enzyme located almost exclusively in the villus tip enterocytes of mammals. Its plasma activity, normally very low, is enhanced by intravenous heparin that releases the enzyme from the enterocytes into the blood. Postheparin plasma DAO (PHD) values have been shown to be significantly reduce...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199731
更新日期:1988-01-01 00:00:00
abstract::The intestinal phase of enterohepatic circulation, such as site and state of bile acid absorption, along the length of the intestinal tract has been speculated but not directly quantitated. In order to gain insight into the actual state of intestinal absorption of bile acid, the bile acid composition of portal blood f...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199790
更新日期:1988-01-01 00:00:00
abstract::94 patients with peptic ulcerations of duodenum, stomach, and esophagus, who did not respond to 3 or more months high-dose (450 or 600 mg) treatment with ranitidine, were treated orally with 40 mg omeprazole daily. After healing all patients were offered long-term maintenance therapy with the same dose for 5 years. In...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199610
更新日期:1988-01-01 00:00:00
abstract::It is now generally admitted that phytohemagglutinin (PHA) constitutes the main factor responsible for the dietary toxicity of raw kidney beans. In the growing rat, an impairment of growth is the unique expression of a malnutrition syndrome. The aim of this work was to precise to what extent the intestinal injuries ma...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199736
更新日期:1988-01-01 00:00:00
abstract::The present study was undertaken to investigate the effect of adrenergic agents on secretion of amylase from the salivary glands in vivo. Saliva was collected from the distal oesophagus in conscious rats. Adrenaline increased the concentration of amylase in saliva and serum significantly. The result of infusion of alp...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199729
更新日期:1988-01-01 00:00:00
abstract::Growth hormone-releasing factor (GRF) was reported to possess the growth-promoting action on the gastroduodenal mucosa that can be augmented by removal of endogenous somatostatin. Since mucosal proliferation was considered to contribute to healing of chronic gastroduodenal ulcerations, we designed the study to determi...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199763
更新日期:1988-01-01 00:00:00
abstract::In an attempt to evaluate a possible correlation between cryptogenic chronic liver disease and a present or past hepatitis B virus (HBV) infection, we studied 17 patients with hepatitis B surface antigen (HBsAg)-negative, nonalcoholic chronic liver disease; 9 of them were positive for serum HBsAg detected by a solid-p...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199633
更新日期:1988-01-01 00:00:00
abstract::The effects of two synthetic prostaglandin E derivatives on mucus glycoproteins in the stomachs of rats were evaluated. Neither derivative caused change in mucus glycoprotein content in the gastric corpus or antrum, but both increased the biosynthetic activity of mucus glycoproteins in these regions (about 15-30%). Fu...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199621
更新日期:1988-01-01 00:00:00
abstract::Previous studies suggested that gastrin-releasing peptide (a neuropeptide found in rat oxyntic mucosa) and oxyntomodulin (a glucagon-containing peptide of mammalian gut) could directly affect the acid secretion of the parietal cells. We therefore studied their effect on gastric acid production in vitro by measuring [1...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199648
更新日期:1988-01-01 00:00:00
abstract::Gastric emptying was measured in 12 patients with chronic duodenal ulceration and compared with the results from 10 healthy volunteers. The test meal of 300 ml 15% dextrose, labelled with 99mTc-DTPA, was ingested in increments over 6 min. Gamma camera imaging proceeded over 30 min, with a 1-min frame time. A direct co...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199660
更新日期:1988-01-01 00:00:00
abstract::The serine protease inhibitor camostate (Foy-305; 200 mg/kg body weight) had been administered twice daily either subcutaneously or orally to mice for 5, 10 and 15 days. Within 5 days, pancreatic weight, concentration of trypsin, amylase and protein were significantly increased and even more increased after 10 and 15 ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199491
更新日期:1987-01-01 00:00:00